Pharmacokinetics and Milk Penetration of Orbifloxacin After Intravenous, Subcutaneous, and Intramuscular Administration to Lactating Goats
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منابع مشابه
Pharmacokinetics of Cefepime Following Intravenous and Intramuscular Administration in Sheep
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The pharmacokinetics and the prostaglandin (PG) synthesis inhibiting effect of flunixin were determined in 6 Norwegian dairy goats. The dose was 2.2 mg/kg body weight administered by intravenous (i.v.). intramuscular (i.m.) and oral (p.o.) routes using a cross-over design. Plasma flunixin content was analysed by use of liquid chromatography and the PG synthesis was evaluated by measuring plasma...
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Ceftiofur sodium administered as a single dose (2.2 mg/kg, IV and SC) resulted in plasma concentrations of active drug similar to those achieved with the approved IM route. By varying dosing intervals after appropriate concentrations are achieved by IV, SC or IM administration should be effective for treatment of bacterial infections caused by susceptible organisms. Therefore, dosage intervals ...
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BACKGROUND Bacterial pneumonia in goats is usually caused by Mannheimia haemolytica and Pasteurella multocida. Another important infection disease in lactating goats is intramammary infection producing mastitis, usually associated with coagulase-negative Staphylococcus spp. However, treatment of bacterial pneumonia in goats not affected by mastitis problems should be restricted to antimicrobial...
متن کاملPharmacokinetics of ceftazidime in buffalo calves following intravenous and intramuscular administration
The pharmacokinetic parameters of ceftazidime, a third generation cephalosporin, were investigated in six buffalo calves after single intravenous (IV) and intramuscular (IM) administration at a dose rate of 10 mg/kg body weight. Ceftazidime concentrations in plasma and urine were determined by microbiological assay. Ceftazidime disposition was best fitted by a two-compartmental and a one-compar...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2007
ISSN: 0022-0302
DOI: 10.3168/jds.2007-0071